Health News 

Finding the triggers of inflammation

TLR-induced inflammasome priming triggers IL-1β and NLRP3 ubiquitylation.

Chronic or acute inflammation can contribute to a range of ailments—some potentially deadly—including stroke, respiratory and heart disease, cancer, arthritis, asthma, dementia, multiple sclerosis, and diabetes. In May, a study by Dr. Kate Lawlor and collaborator Professor Vince James (WEHI) published in Nature Communications shed light on the potential triggers of inflammation.

The research focused on the cytokine, interleukin-1ß (IL-1ß), which is critical to clearing infections but is also associated with sepsis and driving autoinflammatory and inflammatory diseases including rheumatoid arthritis, type 2 diabetes, and atherosclerosis.

Previous IL-1ß research had focused on understanding how it is triggered and how inhibiting this process or neutralizing IL-1ß could reduce inflammation. However, little was known about how the precursor IL-1ß protein is regulated.

Source: Read Full Article

Related posts:
  1. New study describes which cancer patients are more vulnerable to COVID-19
  2. Have to wear sanitary pad with diaper for hours: Female doctors on challenges of wearing PPE
  3. Only 15% of unemployed adults in NC gained Medicaid coverage during the pandemic, finds study
  4. WHO strongly recommends antiviral drug for patients with non-severe COVID-19