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It is time to start solving the mystery of Long COVID, an aspect of the pandemic blighting millions of lives, the World Health Organization’s leader on post-COVID conditions told AFP.

Little is known about why some people, synthroid order on line after coming through the acute phase of COVID-19, struggle to recover and suffer ongoing symptoms including tiredness, brain fog, cardiac and neurological disorders.

At this stage of the pandemic, the world is fixated on vaccine roll-out and new, more contagious variants of the coronavirus.

However, Long COVID deserves similar urgent attention, said Janet Diaz, the clinical care lead in the WHO’s emergencies programme, ahead of a push for a globally-unified approach to the problem.

“We still don’t fully understand what Long COVID is,” Diaz told AFP in an interview outside the WHO’s headquarters in Geneva.

“There’s quite a bit to learn, but I am confident that the scientific community is really rallying around.”

Tellingly, Long COVID does not yet have a proper name.

The WHO currently calls it post-COVID condition, while other terms in circulation include post-acute COVID syndrome and COVID long haulers.

Building up a picture

The WHO is hosting a first global seminar on Long COVID on February 9. It will bring scientists, experts and clinicians together to define the condition, give it a formal name and harmonise study methods.

“It’s a condition that needs further description, further understanding of how many are affected and further understanding of what is causing it, so we can better prevent, manage and treat it,” said Diaz, 48, a US respiratory physician and intensive care doctor.

She said British and other studies suggested potentially one in 10 cases may have prolonged symptoms one month after infection, but there was no picture yet of how long those conditions might persist.

The elderly and those with underlying conditions are most at risk of serious disease from COVID-19.

But the profile of Long COVID patients does not match. It affects people with varying degrees of severity of disease and “seems to potentially also include younger people”, including children, said Diaz.

While the pandemic response priority remains preventing people from catching the virus and falling ill, treating coronavirus cases “must also now include care after the acute illness… until you get back to full health”, Diaz said.

Cracking the code

Diaz said fatigue seemed to be the most common symptom, with others including post-exertional malaise, cognitive dysfunction or brain fog, shortness of breath, heart palpitations and neurological problems.

“How these are all related—that’s what we don’t understand. Why would one person get this, and the other person get that?” asked Diaz, saying researchers needed to crack the underlying mechanisms of the disease that were causing these persistent symptoms.

“Is it something due to the virus? Due to the immune response? If we had a better idea, we could start to target some interventions to reduce symptoms.”

Diaz said a “tremendous amount” of research was underway, largely classic observational studies following discharged patients.

The first COVID-19 cases were discovered in China in December 2019. But it was only when Long COVID started appearing on the radar months later that mystified sufferers began reaching out and joining the dots themselves.

“That’s been a tremendous movement,” said Diaz, who took on the Long COVID remit in October.

In the first wave of the pandemic, struggling health care systems got patients through the acute illness, “but then didn’t realise they weren’t recovering to their previous health”.

She said the patient-led research had driven scientists to do further studies, and “collaboratively we should get to an answer quicker”.

‘Stay hopeful’

The February 9 seminar, at which scientists will present their latest findings, will be the first in a regular series.

“Right now, we probably have enough descriptive data to start to bring it all together,” said Diaz.

Besides agreeing a definition and a name, the meeting will launch a standardised data collection methods for monitoring patients, and start opening doors towards clinical prevention and management.

“We quickly have to build our understanding from each other’s experiences,” Diaz said.

Crucially, donors will be taking part, and are “really aware” of the pressing need for Long COVID funding, she added.

In a message to the potential millions still suffering long after they are officially considered recovered, Diaz said: “Stay hopeful”.

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