COVID-19 vaccination safe during pregnancy

(HealthDay)—Maternal vaccination with the Pfizer-BioNTech COVID-19 vaccine in pregnancy is safe and not associated with detrimental outcomes to the offspring, according to a study published online Feb. 10 in JAMA Pediatrics.

Inbal Goldshtein, Ph.D., from Maccabi Healthcare Services in Tel-Aviv, Israel, and colleagues examined whether BNT162b2 mRNA vaccination during pregnancy is associated with adverse neonatal and early infant outcomes among the newborns. Analysis included 24,288 eligible singleton live births in March through September 2021, within a large state-mandated health care organization (16,697 exposed to vaccination).

The researchers observed substantial differences in preterm birth rates between exposed and unexposed newborns (risk ratio [RR], 0.95; 95% confidence interval [CI], 0.83 to 1.10) or small birthweight for gestational age (RR, 0.97; 95% CI, 0.87 to 1.08). There were also no significant differences seen in the incidence of all-cause neonatal hospitalizations (RR, 0.99; 95% CI, 0.88 to 1.12), postneonatal hospitalizations (RR, 0.95; 95% CI, 0.84 to 1.07), congenital anomalies (RR, 0.69; 95% CI, 0.44 to 1.04), or infant mortality (RR, 0.84; 95% CI, 0.43 to 1.72).

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