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In a study published in the Journal of Bone and Mineral Research, investigators developed and validated a genetic risk score for predicting the onset and severity of the most common type of scoliosis in adolescents–called adolescent idiopathic scoliosis (AIS). AIS causes spinal deformities in as many as 3% of youth, and because its heritability is high, genetic data could help improve detection.

Use of the score may help clinicians identify children at risk of developing AIS who could benefit from preventive therapies.

We found that a risk score based on genome-wide association study data could predict not only susceptibility to AIS, prednisolone 5mg for dogs uk but also its severity. We hope our findings will be useful for personalized medicine."

Chikashi Terao, MD, PhD, Study Senior Author, Center for Integrative Medical Sciences, RIKEN

Source:

Wiley

Journal reference:

Otomo, N., et al. (2021) Polygenic Risk Score of Adolescent Idiopathic Scoliosis for Potential Clinical Use. Journal of Bone and Mineral Research. doi.org/10.1002/jbmr.4324.

Posted in: Child Health News | Medical Research News | Medical Condition News

Tags: Adolescents, Bone, Children, Genetic, Genome, Medicine, Personalized Medicine, Research, Scoliosis

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