Do Migraines Increase Risk of Stroke?

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• What is a stroke?
• Migraines: causes and treatments
• Migraines and strokes
• Can migraines contribute to strokes?

Migraines and strokes are neurological disorders, and those affected by migraines are known to be at increased risk of stroke. However, an explanation for this association remains elusive. It is not yet known whether migraine itself predisposes to stroke, or whether persons affected by migraines have another, unknown risk factor that increases their risk of stroke.

What is a stroke?

A stroke occurs when the blood supply to the brain is interrupted. This causes affected neurons and other brain cells to be starved of oxygen, killing them.

There are three main types of strokes; Ischemic stroke, hemorrhagic stroke and transient ischemic attack (a warning or “mini-stroke”). A hemorrhagic stroke results from a burst blood vessel in the brain that causes a bleed around the local area.

The causes of hemorrhagic strokes include high blood pressure, and to a lesser extent and brain aneurysms (rupturing of balloon-like expanses of blood vessels). Ischaemic strokes are more common and are characterized by the blockage of blood flow to regions of the brain due to a blood clot.

These blood clots can be formed due to atherosclerosis deposits in the blood vessel of the brain or due to the lodging of a blood clot that has travelled from another area of the body.

Risk factors for ischaemic strokes include smoking, high blood pressure, obesity, high blood cholesterol, and diabetes mellitus.

Migraines: causes and treatments

Migraines are a form of moderate/severe headache that affects approximately 20% of women and 6.67% of men. There are several types of migraine which vary based on the expression.

Migraines that have warning signs before the migraine attack begins are called migraine with aura. Migraines without prior warning signs are called migraine without aura.

Silent migraines are migraines without headaches but with other migraine symptoms. Some of the other symptoms of migraines are feeling/being sick, increased photosensitivity, increased noise sensitivity (hyperacusis), poor concentration, and abdominal pain.

Additionally, the warning signs before an aura/silent migraine range from vision problems, to dizziness, and even difficulty speaking and loss of consciousness.  Some of these symptoms resemble stroke symptoms.

Migraines usually progress in stages, although not all stages are met or expressed in order for every migraine, even in the same patient. These stages are;

1. Prodrome – changes in mood, energy levels, or behavior before a migraine attack.
2. Aura – the warning signs that occur before a migraine attack occurs (such as visual changes). Migraine without aura attacks does not express this stage.
3. Headache – Pulsating/throbbing pain originating in the head, which can also be accompanied by additional symptoms, as previously discussed. These are often one-sided but can be bilateral.
4. Resolution – when the symptoms begin to fade and the migraine attack ends.  

Migraines and strokes

Migraines and strokes are heavily linked as they are both neurovascular disorders with similar physiological properties.

Migrainous infarction is the occurrence of a stroke during a migraine attack, with symptoms that persist for longer than 60 minutes. The incidence of this disorder is exceptionally low, with only 0.2-0.5% of all ischaemic stroked being migrainous infarction.

The posterior blood circulation of the brain is more affected than the anterior circulation during a migrainous infarction. This results in visual deficits, sensory deficits, inability to form/comprehend language (aphasia), weakness of one side of the body (hemiparesis), and weakness of all four limbs (tetraparesis).

The prognosis for migrainous infarctions is favourable, with most cases showing a complete recovery.

One theory for the relationship between  migraine and stroke is the cortical spreading depression (CSD) hypothesis. This theory suggests that a decrease in cerebral blood volume starts during the aura phase of a migraine and spreads anteriorly through the brain; this stage is followed by an increase in blood flow to different tissues. Ultimately, this results in the migraine aura attack. Patients with migraine without aura show posterior hypoperfusion.

A potential response to CSD is severe vasoconstriction instead of vasodilation, which is detrimental to the health of the brain. Due to the low incidence of migrainous infarctions and the high incidence of migraines, is it clear that the cerebral blood flow during a CSD does not cause ischaemic stroke in the vast majority of cases. This suggests that CSD may only be a factor of migrainous infarctions instead of a direct cause.

Can migraines contribute to strokes?

Population studies have shown that patients with migraines are twice as likely to suffer from an ischaemic stroke compared to individuals that do not suffer from migraines.

Risk factors for migrainous infarction include young age (under 45 years of age), being female, smoking, and use of oral contraceptives.

An important distinction is that increase risk of strokes due to migraines has only been observed with migraine aura, with migraine without aura showing no increased risk. Theories discussing the increased risk of ischaemic stroke and migraines include:

• The migraine predisposing an individual to ischemic strokes
• Common comorbidities between migraine and stokes
• Certain genetic disorders associated with migraines and strokes
• Migraine-specific medication – I.e. vasoconstrictors – that increase the risk of a stroke

As of 2015, 38 different gene loci have been linked to migrainous infarctions. One of those is a polymorphism in the methylenetetrahydrofolate reductase gene. This gene is responsible for the metabolism of folate and homocysteine and is associated with increased susceptibility to migraine auras.

Cerebral Autosomal Dominant Arteriopathy with subcortical infracts and leukoencephalopathy (CADASIL) is a disorder of small cerebral arteries that is associated with migraines and ischaemic strokes. Ischaemic strokes occur in approximately 60%-85% of patients with CADASIL.

Mitochondrial encephalopathy lactic acidosis and stroke-like episodes are a genetic heterogeneous mitochondrial disorder which results in many neurological symptoms mainly affecting the central nervous system. This includes seizures, cortical blindness, episodic vomiting, migraines, and stroke-like episodes.

Further Reading

• All Migraine Content
• What are Migraines?
• Migraine Diagnosis
• Migraine Pathophysiology
• Migraine History

Written by

Samuel Mckenzie

Sam graduated from the University of Manchester with a B.Sc. (Hons) in Biomedical Sciences. He has experience in a wide range of life science topics, including; Biochemistry, Molecular Biology, Anatomy and Physiology, Developmental Biology, Cell Biology, Immunology, Neurology  and  Genetics.