Alex Lloyd examines what can be done if you discover cancer runs in your family
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Scientists are still learning about the role hereditary gene faults play in the disease, but the information we already have can give families blighted by cancer the chance to change the course of their future.
“It’s a scary thing to be told you have been born with a higher-than-average lifetime risk of cancer,” says Jo Stanford, cancer prevention officer for Ovarian Cancer Action. “But this knowledge means you are right at the front of the queue for referrals, screenings and risk reduction options.
“My mum died of ovarian cancer and I felt very helpless.
“Discovering I inherited a genetic fault allowed me to take back control and it will now be a different story for my children.”
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How can cancer be in my genes?
Your genes are an instruction manual for your body so it can make proteins, the building blocks of life.
All cancers develop because something has gone wrong with one or more of the genes within a cell, leading it to divide and grow uncontrollably.
The vast majority of these faults occur due to factors such as your age or lifestyle. But a small proportion are hereditary.
“When you have a fault, it’s like having a spelling mistake in the instructions so your body can’t do its job as well,” explains Jo.
“But it’s important not to panic, as only five to 10 per cent of all cancer cases have a hereditary element.”
Ovarian, breast, prostate, pancreatic and bowel are some of the types you can be more likely to get if you carry a mutation, but the lifetime risk levels vary between cancers and carriers.
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What are the gene faults?
There are two main types that we know about so far – BRCA mutation and Lynch syndrome.
All of us carry BRCA genes, otherwise known as tumour suppressors, and their job is to repair cell damage and prevent cells growing and dividing too rapidly. But some families have faults on the BRCA1 and BRCA2 genes which make them less effective.
It’s thought around one in every 400 to 800 people are carriers of these faulty genes, but this is significantly higher for people with certain backgrounds, such as Ashkenazi Jews.
The BRCA mutation has a strong link with breast and ovarian cancer but it’s just as important for men to know if they carry it as women.
This is because it also raises the risk of prostate and pancreatic cancers, while dads can pass the fault down the generations. Lynch syndrome is an umbrella term for mutations on a group of genes that should repair DNA damage when cells divide – MLH1, MSH2, MSH6 and PMS2.
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How do I know if I’m a carrier?
If either of your parents has a BRCA mutation or Lynch syndrome, there is 50 percent chance you will too. You only need to inherit one faulty copy to have an increased cancer risk and this can be confirmed by having a blood test. But because testing is relatively new and patchy, most of us remain unaware if these mutations are hidden in our DNA.
Looking at your family history is the best indicator of whether you should consider screening.
Jo says: “One blood relative with cancer is unlikely to be a red flag to make you eligible, but it depends on the type.
“Generally, you need to have two or three relatives with specific cancers.
“I’d recommend compiling a family tree listing any cancers and health problems on both sides.
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“Next, put this information into the hereditary cancer risk tool on our website ovarian.org.uk to see whether you might meet the referral criteria.
“This also gives you a printout with the information your GP will need, and the NICE guidelines.”
Anyone referred for testing on the NHS will be able to access a genetic counsellor before and after, who can explain the process, your personal risk factors and how to tell relatives about a diagnosis.
If you’ve had bowel or womb cancer or are undergoing treatment for either, doctors should screen your tumour for signs of Lynch.
Jo recommends chasing this up if they haven’t.
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Does being a carrier mean I’ll get cancer?
No. Nothing is inevitable and having the knowledge means you can take action to reduce the risks.
“Our generation are the first ones able to use this information and it is empowering to be able to do that,” explains Jo.
While people with Lynch see their lifetime risk of developing bowel cancer increase from 5.5 per cent to as much as 80 per cent, knowing you have this predisposition can be the difference between life and death.
You’ll be aware of symptoms of concern, be offered regular screenings to detect any changes and you’ll be able to make lifestyle changes to protect your health.
Regular colonoscopies for Lynch carriers can reduce the risk of dying of bowel cancer by 72 per cent.
There are also options for riskreducing surgery, such as elective mastectomies and hysterectomies, while carriers without children can access a form of embryo screening that checks for BRCA mutations and Lynch on the NHS, called PGT-M.
Jo – who opted for preventative surgery when she was in her 30s – says: “These are not easy choices. It’s scary to have body parts removed, it can be lonely and it’s not the right decision for everyone.
“But for those of us who have lost a loved one to cancer, the opportunity to take back the power and say ‘this stops with me’ is wonderful.”
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Dad carried lynch fault
Laura Palmer-Hukins was just a few weeks pregnant with her second daughter when her dad was diagnosed with bowel cancer – the disease that had killed his own father.
After surgery to remove his colon, genetic tests revealed Terry had Lynch syndrome.
Shortly after Laura gave birth in August 2018, doctors said the cancer had spread to his lungs, liver, kidneys and spine.
He died three days before Christmas that year, aged just 62.
Desperate not to go through the same agony, Laura and her brother were tested for Lynch. In May 2019, the results showed only one sibling had inherited a particularly highrisk mutation on the MSH2 gene – Laura.
Her sex meant she was at higher risk of ovarian and womb cancer, as well as bowel cancer like her dad. “My first reaction was to ask how soon I could have a hysterectomy,” says the 35 year old. “I felt like my body could betray me at any moment.
“Doctors think I’m young for this procedure but I’ve had my children and I’ll do whatever it takes to see them grow up.
“Suffering from extreme menopause is better to me than the alternative.”
Knowing she carries a hereditary cancer gene means Laura tries to cherish every moment with her daughters Minnie, five, and Etta, three.
She also married long-term partner David in February 2020. “Living with Lynch is a rollercoaster of emotion – every ache and pain comes with extra worry,” she explains.
“There are constant hospital appointments to think about and invasive tests.
“I also feel guilt that I may have passed this onto my girls, but I’m glad I have the knowledge to modify the risk.”
The mum-of-two from Pocklington, East Yorks, is dedicating herself to raising funds for Lynch research and raising awareness too.
She remains on the surgery waiting list and says her desire to have the op has only increased since her uncle – another Lynch carrier – died of an unrelated cancer during the Covid-19 pandemic.
“I want more families to look into their own health histories and take control.
“Dad knew there was bowel cancer in the family but not about the gene, so he missed a couple of screenings. Had he realised how serious it was, I think he could still be here.”
- Find out more about hereditary cancer at ovarian.org.uk
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